Royal Air Force Typhoon FGR4s have conducted a mission with France's air force in a joint strike on an hidden munitions depot in Syria used by the IS group, according to the UK Ministry of Defence.
The facility, located using surveillance, was thought to be storing arms and explosives, the release indicated, and was positioned in hills just north of Palmyra in the heart of Syria.
"The RAF jets used Paveway IV guided bombs to hit a number of access tunnels down to the facility... initial indications indicate the strike was effective," the MoD said.
There was no sign of any civilian impact in the strike late on Saturday and each participating jet made a safe return, the defence officials confirmed.
The Typhoon FGR4s were supported by a Voyager tanker plane.
IS - alternatively referred to as the so-called Islamic State - established militant control over large swathes of Iraq and Syria prior to its 2019 collapse.
"This operation underscores our UK leadership, and determination to stand shoulder to shoulder with allied nations, to eliminate any resurgence of the terrorist group and their violent and radical beliefs in the Middle East," the British Defence Secretary the Defence Secretary said.
RAF aircraft have carried out surveillance missions over Syrian airspace to "prevent any efforts to regroup" of the group after its defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I extend gratitude to all the members of our armed forces involved in this strike for their expertise and their bravery," Healey commented. "They were part of numerous British personnel deployed over the holidays. This mission, to eliminate militants who pose a risk to our safety, shows how British military are always on standby, continuously, protecting the UK at home and strong abroad."
Last December, the American forces conducted what it described as a "large-scale strike" against Islamic State objectives in the country, following an attack resulted in the deaths of two American soldiers and a civilian linguist in Palmyra.
The United Nations reports IS still maintains roughly 5-7 thousand fighters in both countries.